Three posters covering topics in renal, bladder and testis cancer were selected as the best unmoderated posters in the last day of EMUC17. The winning studies were led by authors based in Spain, Italy and Sweden.
The closing plenary session opened with the awarding of prizes to Francesco Gatto (SE), Andrea Necchi (IT) and colleagues, and Jose Luis Bauza Quetglas (ES). They won in the renal, bladder and penile/testicular cancers, respectively.
Below are the summary conclusions of the studies:
Renal Cell Carcinoma Category
Abstract P093: Plasma glycosaminoglycan scores in early stage renal cell carcinoma
Author: Gatto F, et al., Chalmers University Of Technology, Dept. Of Biology And Biological Engineering, Gothenburg, Sweden
No diagnostic blood biomarker for RCC is currently used in the clinical routine. Using a systems biology approach, the researchers previously developed a score based on circulating glycosaminoglycans (GAGs) that detected metastatic clear cell renal cell carcinoma (RCC) with 92.6%, 93.7%, and 100% accuracy vs. healthy subjects using either plasma, urine, or combined measurements in a validation cohort (Gatto et al., 2016, Cell Reports).
The researchers concluded that interim analyses revealed that plasma GAG scores have the potential to differentiate samples from RCC versus healthy subjects with remarkable AUC, ranging 0.866 to 0.999 depending on the different formula variations.
Abstract P143: Pattern of relapse after perioperative chemotherapy and radical cystectomy versus radical cystectomy alone in patients with muscle-invasive bladder cancer (MIBC): A multicenter study
Author: Necchi A. et al., Fondazione Irccs Istituto Nazionale Dei Tumori, Medical Oncology, Milano, Italy.
Neoadjuvant (NACT) and adjuvant chemotherapy (ACT) improve relapse-free survival (RFS) and overall survival (OS) of patients (pts) with MIBC. To date, limited information is available as to whether perioperative chemotherapy (POC) administration leads to different patterns of relapse after radical cystectomy (Cy), compared to Cy alone. Obtaining this information may be useful to optimize the treatment of patients (pts) with MIBC.
In this large multicenter study, POC confirmed to be effective in prolonging RFS for MIBC. The independent effect of POC was mainly seen on the risk of developing RL, while more potent systemic therapies are needed to improve the systemic disease control outside of the pelvis. These results will be used to develop risk tools (nomograms) to assess the RL vs RD probability to optimize standard therapy, follow-up, and the design of clinical trials. These nomograms were presented at the meeting.
Testicular and Penile Cancer
Abstract P163: The neutrophil to lymphocyte ratio role in the testicular cancer
Author: Bauza Quetglas J.L. et al., Hospital Universitario son Espases, Dept. of Urology, Palma de Mallorca, Spain
Neutrophil to Lymphocyte Ratio (NLR) has been pointed out as a poor prognostic factor in many tumors. The researchers assessed the usefulness of the NLR in testicular cancer and it’s correlation with pathology grade, classic Tumor Markers (TM), the need of chemotherapy and recurrence.
“NLR is a highly accessible test, independent from TM, significantly different in those who receive chemotherapy, and linked to better time until recurrence if value lower than 2.255. More evidence is neccessary to assert its use.,” the researchers reported.